1. It is also inert and biocompatible. It is available in different grades and particle sizes. MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. Learn about FMC's industry leading goal of net-zero emissions by 2035. Medium size standard MCC grade, suited for the majority of directly compressible actives. %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. HMo@9, U Q!R/1*;` This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. endobj LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . Van Veen, G.K. Bolhuis, Y.S. Microcrystalline Cellulose (MCC) Manufacturing Industry. % Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Avicel RC-591 offers ideal thixotropic bahavior for stabilizing suspensions while Avicel CL-611 is a stabilizer for reconstitutable or dry suspension formulations. Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. Heavy metals, % NMT 0.001 6 Avicel PC 611 (FMC Biopolymer) . Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more. Chemical Formula: (C6H10O5)n 1.4. Comments: The human studies including the use of radiolabelled microcrystalline cellulose show complete absence of digestion or absorption. Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. Although the breakup of cellulose to form colloidal microcrystalline cellulose has no impact on calorific content of the material, colloidal microcrystalline cellulose contain soluble components (hydrocolloids) that are introduced during processing, which add calories to the product. Find answers in our support articles. METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. Some substance identifiers may have been claimed confidential, or may . They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. endobj ). We know that our customers need to provide reliable and consistent products to their patients. Aquacoat CPD is an aqueous dispersion of cellulose acetate phthalate used for enteric release applications. By producing Avicel . YUMPU automatically turns print PDFs into web optimized ePapers that Google loves. CAS #: 9004-34-6 1.6. Millipore. The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. No. Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. (Microcrystalline Cellulose Market Pr. MATERIAL SAFETY DATA SHEET. Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. l~5C Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * No. Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. <> Go to Investor Relations. The most. gwf;J(e0o|1p{R~P^);ao!%{0KD7. Your file is uploaded and ready to be published. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. . EMCOCEL 90 M. 130. MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. Protect them from sunshine or rain. 8 0 obj Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). gac74 [#B6`Wnw7 Avicel PH-101. Have an order or account question, find answers in our Online Support articles. "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. Kristensen, T. Schfer, P. Kleinebudde, Direct pelletization in a rotary processor controlled by torque measurements. Htn@sHaYoEJ*H[G&o)o9;0s N'3[*%M]vAu#9Tqpg9D& Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. . In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine It is a white, free-flowing powder. The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. Alginates from IFF are an excellent choice for consistent performance in a variety of applications. Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture. The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. CAS No. /Group << /S /Transparency /CS /DeviceRGB /I false /K false >> CAS 9004-34-6. endobj Product Name: Microcrystalline Cellulose E460 1.2. It is also used in plaque assays for counting. You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. The cellulose molecule is formed through repeated condensation of cellobiose units. No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . Instead, they obtained a stable colloidal suspension. microcrystalline cellulose and carboxymethylcellulose sodium NF, Ph. vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@ qaj/QU<5OrVMfl{pL? zW0} kAmS AYiy QJVWwi ED`52u-I~_ViT3+3kIT D2/A5vP5MHt(*vCBZ5UALFS0Mr v6t3dDda!03O$V>S6n| 3Fz. United Nations Sustainable Development Goals, Alginates Protanal, Manucol, Protacid and More, Barrier membrane, Controlled release hydrophilic matrix, Taste masking, Carrageenan Gelcarin, Viscarin and More, Controlled release hydrophilic matrix, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Rheology modifier, Rheology modifier/stabilizer, Binder, Controlled release hydrophilic matrix, Rheology modifier, Rheology modifier/stabilizer, Shell - hard capsule, Tablet coatings, Thin films, Topical, Capsules, Other, Solutions, Suspensions, Tablets, Controlled release hydrophilic matrix, Hot melt extrusion, Muco-adhesive, Osmotic pump, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Topical. } !1AQa"q2#BR$3br They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. stream Validity Area. When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. MCC helps in the formation of spheres because of its . MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. /Type/Page Generally, these can be classified into two broad groups: Standard grades, and Co-processed grades. In 1964 FMC, Corporation . Chemical Formula: (C6H10O5)n 1.4. FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . It should be noted that native cellulose itself is completely indigestible, and its hydrolysis during the production of microcrystalline cellulose does not alter its behaviour in the intestine. Date Approved: 05/25/2010. The product would later go on to be commercialized under the brand name Avicel by FMC Corporation. The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. Doses up to 30 g per day appear to be . 1.3. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . /Parent 3 0 R PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. Synonyms: Cellulose, Cellulose powder, Cotton linters. }o]X4]. JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . <> Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER Superior Performance: Provides excellent water uptake and rapid swelling . 130. Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . Micro Crystalline Cellulose. II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. SCMm_>x^O9l (n. J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P PDF (2.77 mb) 2021 FMC Sustainability Report. FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. If breathing is difficult or if . GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. <> Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. Magazine: Material safety data sheet - FMC Corporation. Earth Supplied Products LLC. %PDF-1.4 Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. : 9004-34-6 Date Approved: 01/31/2008 . Microcrystalline cellulose (C6H10O5)n is refined wood pulp. *r_ *?~4$ &0Y# 2008-2023 ChemPoint. INCI. CAS 9004-34-6, pH 5 - 7.5. Revision No. on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . ]2}Sb2Wdn-;^}n(/;r\'l3--l~ kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM !(!0*21/*.-4;K@48G9-.BYBGNPTUT3? An agricultural sciences company. The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. It is . As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. . stream Are you sure you want to delete your template? It is hygroscopic and insoluble in water. PDF (4.11 mb) Footer menu 1. This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. : 51395-75-6 Date Approved: 01/31/2008 Revision No. In large quantities it provides dietary bulk and may lead to a laxative effect. Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. Performing this action will revert the following features to their default settings: Hooray! Regulatory Information Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. Powder becomes slippery when wet. EMCOCEL XLM 90. Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? Material safety data sheet - FMC Corporation. pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. SUBSTANCE IDENTIFICATION 1.1. Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. Microcrystalline Cellulose (MCC) MSDS 1. As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. Well-recognized product that can do it all. METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. Delivering efficient and robust formulations. : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. If you are already a ChemPoint customer then sign up for access to our online ordering website. /Contents 4 0 R Alginates also function as actives in some anti-reflux products. stream The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Material Name: Estradiol Tablets Trade Name: RONFASE . Home. In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. >> endstream : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against stream Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. Battista, O. Microcrystalline Cellulose. DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. 2 0 obj cas:9000-11-7 msds Carboxymethyl cellulose. Product Name: Microcrystalline Cellulose 1.2. It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. 4. SDS - Safety Data Sheet. : 1. Remove JFIF ` ` ZExif MM * J Q Q Q C AVICEL RC 581. ETHOCEL premium ethylcellulose resins are water-insoluble polymers. The table below shows the most common physicochemical parameters of this raw material. CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. No. Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. CAS #: 9004-34-6 . PharmaCentral 2021 . P}MFbN#[>r(y Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. : 5. 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. Meet our leadership team. 4 0 obj Combines good flow and high compactibility. w !1AQaq"2B #3Rbr MATERIAL SAFETY DATA SHEET. Aqueous suspensions of microcrystalline cellulose have . AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. lH5JWy}DgKRR"Fs Cellulose microcrystalline. BIOACCUMULATIVE POTENTIAL Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? Quick Links. Avicel RC-591 & CL-611 - Description. Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. The aqueous solution to barrier membrane coating. Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. Truly distinctive drug delivery solutions. Catalog Number 102331. msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Eur., JPE . Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. Molecular weight: Not Applicable 1.5. Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. <> 4 0 obj The data shown below apply only to Avicel PH 101. More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. q86@on$^X_HuH;3` ( /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.) Cellulose microcrystalline for column chromatography. . Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. /PRNewswire/ -- ReportsnReports added Global Microcrystalline Cellulose (MCC) Market Growth 2019-2024 to its online research database. : CL-611NF Date Approved: 01/13/2010. Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. The figure below illustrates the structural organisation of cellulose within plants. 86dXeaAjHe%d*`&>>&_p}=X|_% fTtC aB s!YaxHWtGr"GQ 5S"fMS+_;x@@5 zjrK=;OA:il)b> e ei'wm~oh!=Z@Y:J0#8On`T./iC}^o%7KS"$ rf*Z;JTL-uOHH%%Z,029J_ ( endstream endobj 526 0 obj 465 endobj 527 0 obj << /Filter /FlateDecode /Length 526 0 R >> stream Document(s): certificate data msds. The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. It is widely used within the pharmaceutical, food, and cosmetic sectors as a formulation aid. Report Category. No. There have always been two different points of view for the liquidity of MCC. B;vLZpHU%ChUyD+[ Explore how we work and why we apply science and creativity for a better world to everything we do. : 160182 Date Approved: 05/25/2010 Revision No. In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no Microcrystalline cellulose -The oldest polymer finds new industrial uses,. Hi, let us know if you have any questions as you visit our website. FMC Corporation. They are made up of sulfated and non-sulfated repeating units of galactose and 3,6-anhydrogalactose. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. Microcrystalline Cellulose Side Effects. Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. POLYOX resins are nonionic polyethylene oxide solubility polymers. It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. Synergies to simplify formulation challenges and reduce operational costs. Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. We respect your privacy FMC Privacy Policy. We can send by Fedex, by ship or by plane according to international rules. [FMC Study Number I92-1464]. Material Safety Data Sheet TALSTAR S INSECTICIDE Version 1 Page 1 / 8 SDS # : 6320-A This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS) requirements. X\o^ G2W4de=u183KGH{ vQ#4:1\wc Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. % Avicel PC 611 Microcrystalline Cellulose. << IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No.
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